Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease.

Enzymes in Dried Blood Spots: Application to Newborn Screening for Krabbe Disease, Yijun Li, Knut Brockmann, Frantisek Turecek, C. Ronald Scott, and Michael H. Gelb (Departments of 1 Chemistry, 3 Pediatrics, and 4 Biochemistry, University of Washington, Seattle, WA; 2 Department of Pediatrics and Neuropediatrics, Children’s Hospital, University of Goettingen, Goettingen, Germany; * address correspondence to this author at: Departments of Chemistry and Biochemistry, University of Washington, Campus Box 351700, Seattle, WA 98195; fax 206-685-8665, e-mail [email protected])